Erasers of Histone Acetylation: The Histone Deacetylase Enzymes
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چکیده
منابع مشابه
Erasers of histone acetylation: the histone deacetylase enzymes.
Histone deacetylases (HDACs) are enzymes that catalyze the removal of acetyl functional groups from the lysine residues of both histone and nonhistone proteins. In humans, there are 18 HDAC enzymes that use either zinc- or NAD(+)-dependent mechanisms to deacetylate acetyl lysine substrates. Although removal of histone acetyl epigenetic modification by HDACs regulates chromatin structure and tra...
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ژورنال
عنوان ژورنال: Cold Spring Harbor Perspectives in Biology
سال: 2014
ISSN: 1943-0264
DOI: 10.1101/cshperspect.a018713